It seems premature to recommend the use of nattokinase in patients who are more willing to take it (as a substitute for warfarin, aspirin, or clopidogrel). In addition, taking NK in combination with the above-mentioned medications may increase the risk of bleeding and should be avoided. Nattokinase (NK), as a serine protease enzyme, has a strong fibrinolytic activity found in bacteria. Nattokinase has the potential to simplify drug use and improve patient compliance with the prevention and treatment of CVD.
Subtilis JNFE012, which produced both nattokinase and the milk-coagulating enzyme, was isolated from traditionally fermented natto and used as a starter for functional fermented milk. In the near future, patients with CVD may only need one NK pill to replace the multiple drugs administered for the prevention and treatment of CVD, including tPA, antihypertensive drugs, statins, aspirin, and warfarin. Nattokinase (NK), a serine protease that has many key beneficial effects on the cardiovascular system, is being sought as a promising alternative agent. The protective effect of ovalbumin and flavonoid hydrogels (naringenin, genistein, naringin, puerarin, and daidzein) on thrombolytic activity and the stability of nattokinase have been investigated.
Fluorescence spectroscopy and molecular coupling analysis revealed that the main interactions between nattokinase and daidzein, nattokinase and genistein were mainly hydrogen bonds, while the main interactions between nattokinase and naringin, nattokinase and puerarin, nattokinase and naringenin were hydrophobic interactions. Nattokinase appears to be one of those drugs that have promising anti-atherosclerotic and lipid-lowering effects. In 1987, Sumi et al. 3 discovered that natto contained a potent fibrinolytic enzyme called nattokinase (NK). Nattokinase (NK) has many beneficial effects on the cardiovascular system due to its thrombolytic solid and anticoagulant activity.
The optimal pH and temperature were pH 7.0 at 40 °C for nattokinase and pH 6.5 and 55 °C for the milk-coagulating enzyme, respectively. Nattokinase (NK), the most active ingredient in natto, has several favorable cardiovascular effects, and its consumption has been linked to a reduction in mortality from cardiovascular diseases.
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