Nattokinase can thin the blood and help dissolve blood clots. This may protect against heart disease and conditions caused by blood clots, such as strokes, heart attacks, and others. Nattokinase dissolves blood clots by directly hydrolyzing the fibrin and plasmin substrate. Converts endogenous prourokinase to urokinase (PoA).
It also degrades the plasminogen activator inhibitor (PAI) and increases the level of tissue plasminogen activator (t-PA). Fibrinogen is a blood protein that increases the risk of blood clots. Nattokinase lowers fibrinogen levels in the blood 11. Nattokinase also promotes healthy blood clotting by activating the body's natural enzymes that break down blood clots once they have formed. Nattokinase has been compared to our clot-dissolving enzyme, called plasmin.
Nattokinase improves the production of plasmin in our body and another enzyme that dissolves clots, urokinase. Nattokinase has been shown to increase tissue plasminogen activator (tPA), a protein that activates plasmin so that it can break down blood clots.12 As tPA increases, so does plasmin and so does the ability to dissolve blood clots, 13. Studies show that nattokinase dissolves blood clots, helping to maintain good blood vessel structure, improving blood flow and reducing the risk of heart disease. Nattokinase is generally safe, but the enzyme's powerful effects can cause complications in people with certain health conditions. Effects of nattokinase, a profibrinolytic enzyme, on red blood cell aggregation and whole blood viscosity Clin Hemorheol Microcirc.
Nattokinase reduces cerebral infarction, fibrinogen and activated partial thromboplastin time against cerebral ischemia-reperfusion injury. Natto is rich in proteins, vitamins and minerals, but most of the health benefits of this food are related to its powerful nattokinase enzyme. In a 26-week study, 82 volunteers were randomly assigned to take 6000 fibrinolytic units (300 mg) of nattokinase a day. Nattokinase (NK), a powerful protein that dissolves blood clots and is used in the treatment of cardiovascular diseases, is produced by the bacteria Bacillus subtilis during the fermentation of soybeans to produce natto.
Nattokinase appears to be one of those drugs that have such promising anti-atherosclerotic and lipid-lowering effects. Seventy-three subjects completed the study and those who took nattokinase had a significant reduction in blood pressure. The benefits of nattokinase are likely due to the combined effect of nattokinase's ability to promote healthy blood clotting, its antioxidant properties, and its ability to maintain healthy lipids. In a research review, nattokinase was shown to help dissolve blood clots, while other studies found that nattokinase supplementation was associated with a decrease in blood pressure.
A new fibrinolytic enzyme (nattokinase) in Natto vegetable cheese, a typical and popular soy food in the Japanese diet. Antihypertensive effects of continuous oral administration of nattokinase and its fragments in rats with spontaneous hypertension. Nattokinase (NK), the most active ingredient in natto, has several favorable cardiovascular effects and its consumption has been linked to a reduction in mortality from cardiovascular diseases. There is no established recommendation on nattokinase, but studies suggest that its health benefits are obtained with an oral dose 100 to 200 milligrams a day.
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