How quickly does nattokinase work?

Our data, which confirmed an increase in fibrinolysis activity and anticoagulant parameters between 2 and 8 hours after NK intake, are consistent with their results.

Nattokinase

dissolves blood clots by directly hydrolyzing the fibrin and plasmin substrate. It converts endogenous prourokinase to urokinase (uPA). It also degrades the plasminogen activator inhibitor (PAI-) and increases the level of the tissue plasminogen activator (T-pa).

Nattokinase can help prevent blood clots, lower blood pressure, and play a role in treating Alzheimer's disease. Nattokinase appears to have the same properties that can help mitigate specific health problems related to the heart and circulatory system—antihypertensive effects of continuous oral administration of nattokinase and its fragments in spontaneously hypertensive rats. The enzyme responsible for natto's health effects, nattokinase, has since been purified and studied extensively.

Animal studies have shown that nattokinase can significantly reduce the increase in fibrinogen seen after a stroke and the severity of the stroke. The intake of nattokinase (NK) may improve blood flow; however, its effects on skin temperature, which is predominantly controlled by blood flow to the surface of the skin, are unknown. Seventy-three subjects completed the study, and those who took nattokinase had a significant reduction in blood pressure. A new fibrinolytic enzyme (nattokinase) is found in Natto vegetable cheese, a typical and popular dietary soy food in Japanese.

In reference to one study, there were no side effects of nattokinase in several clinical trials. The length of the heparin chain is a factor in determining whether nattokinase can interfere with heparin functions. The combination of nattokinase and red yeast rice has the potential to lower cholesterol more effectively than if nattokinase were administered as a single remedy. After 60 days of nattokinase supplementation, participants were able to control their blood pressure and cholesterol better, in addition to improving their physical activity and quality of life.

Nattokinase seems to have the potential to have a positive impact on the inflammation circuit and control inflammation by preventing pro-inflammatory activities in the body. It improves the effectiveness of nattokinase by also helping to improve inflammation, circulation, and cardiovascular benefits. In another small study, nattokinase combined with standard care (SOC) may help in the rehabilitation of a stroke.