If you take any medications regularly, talk to your doctor before starting to use nattokinase supplements. Supplements may interact with blood thinners and other drugs that reduce clotting, such as aspirin and ibuprofen. They may cause excessive bleeding and bruising. Taking nattokinase together with medications that also slow blood clotting may increase the risk of bruises and bleeding.
Nattokinase (NK) was first introduced as a natural drug that can be administered as a mild anticoagulant. It is a natural drug that can be administered both as a single agent and in pharmacological combinations. Although the positive effects and advantages of the drug outweigh the possible complications described, patients under treatment should always be monitored to check laboratory parameters in order to maintain the balance between hypercoagulation and hypocoagulation. In fact, patients in monotherapy with nattokinase or in pharmacological combinations in which one of the drugs prescribed is nattokinase are at risk of thrombus formation or suffer from bleeding and bleeding.
However, to establish the safety of pharmacological treatments of this type, it is necessary to control coagulation parameters and ensure their stability over time, even in the case of drugs that are known to have mild or no side effects. The coagulation profile, renal function, diet, clinical status, weight and age of the patient should be considered as reference parameters. Monitoring involves both the constant testing of laboratory parameters and the availability of the results a few hours after the collection of the blood sample to allow the necessary pharmacological corrections to ensure patient safety. In fact, healthy values outside the reference range increase the risk of adverse effects.
In conclusion, the available evidence suggests that NK is a unique natural compound and represents an effective and safe treatment for patients with vascular diseases with medical or surgical indications. The indication of nattokinase may be useful in patients chronically treated with heparin. This information relates to an herbal, vitamin, mineral, or other dietary supplement. The FDA has not reviewed this product to determine if it is safe or effective and it is not subject to the quality standards or safety information-gathering standards that apply to most prescription drugs. This information should not be used to decide whether or not to take this product.
This information does not guarantee that this product is safe, effective, or approved to treat any patient or health condition. This is only a brief summary of general information about this product. It does NOT include all information about the possible uses, instructions, warnings, precautions, interactions, adverse effects or risks that may correspond to this product. This information is not specific medical advice and does not replace information you receive from your healthcare provider. You should talk to your healthcare provider for full information about the risks and benefits of using this product.
The easiest way to search for drug information, identify pills, check for interactions and create your own personal drug record. Available for Android and iOS devices. Nattokinase is an extracellular enzyme secreted by the bacteria Bacillus subtilis, which is used to ferment boiled or steamed soybeans, resulting in a preparation called nattō. Nattokinase can help prevent blood clots, lower blood pressure, and play a role in treating Alzheimer's disease. In a study with rabbit platelets, nattokinase inhibited platelet aggregation induced by collagen and thrombin.
Fragments of the nattokinase peptide reduced plasma angiotensin II, but they had no effect on renin or ACE activity. Taking nattokinase together with medications that lower blood pressure can cause blood pressure to drop too low. Cases of thrombosis have been reported following the replacement of warfarin with nattokinase in a patient with a mechanical aortic valve. Attention to the clinical evolution of patients, the monitoring of the INR and the timely and frequent adjustment of doses are the pillars of the safety of care for patients receiving fibrinolytic drugs as a single treatment or in a pharmacological combination.
While there are some small short-term studies on nattokinase, studies are needed more spacious and well-designed. A new fibrinolytic enzyme (nattokinase) in Natto vegetable cheese, a typical and popular soy food in the Japanese diet. Nattokinase may have potential uses in heart-related conditions, such as high blood pressure, high cholesterol levels, and stroke. More high-quality research is needed with larger, well-designed clinical trials to evaluate the efficacy and safety of nattokinase.
In theory, nattokinase can cause an existing clot to break off and cause a stroke or an embolism in a distant location. Dietary supplementation with nattokinase suppressed intimate thickening, modulated wall thrombus lysis, and improved arterial blood flow more effectively than plasmin and elastase.
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