How long does nattokinase take to work?

Our data, which confirmed an increase in fibrinolysis activity and anticoagulant parameters between 2 and 8 hours after NK intake, are consistent with their results.


dissolves blood clots by directly hydrolyzing the fibrin and plasmin substrate. It converts endogenous prourokinase to urokinase (uPA). It also degrades the plasminogen activator inhibitor (PAI-) and increases the level of the tissue plasminogen activator (T-pa).

Nattokinase can help prevent blood clots, lower blood pressure, and play a role in treating Alzheimer's disease. In a clinical trial, 47 subjects with high cholesterol levels (hyperlipidemia) received only nattokinase, nattokinase, and red yeast rice extract, or a placebo for 6 months. In a study with 79 hypertensive patients, vWF was reduced by 15% in the group that took nattokinase, compared to the placebo group, which showed no consistent changes during the 8 weeks. Nattokinase treatment did not begin to lower blood cholesterol and triglyceride levels until the last month of the study.

A small clinical trial on nattokinase in people without cardiovascular disease found no significant benefit in preventing heart disease. Nattokinase is produced by the bacteria Bacillus subtilis natto and is found in the traditional Japanese fermented soy food called natto. However, combination therapy (nattokinase and red yeast rice) reduced levels of LDL, total cholesterol and triglycerides, and increased HDL from the first month. Nattokinase may have potential uses in heart-related conditions, such as high blood pressure, high cholesterol levels and strokes.

After 60 days of nattokinase supplementation, participants had better control of their blood pressure and cholesterol, as well as improvements in physical activity and quality of life. Intervention with serrapeptase and nattokinase to alleviate the physiopathology of Alzheimer's disease in a rat model. Before taking nattokinase, contact your pharmacist or healthcare provider to help you safely achieve your health goals. Nattokinase may work in a similar way to the ginkgo supplement, which is also promotes its benefits for heart health.

In a study comparing nattokinase with statins (cholesterol-lowering drugs), 82 patients were randomly divided into one of these treatments for 26 weeks. In addition to reducing stroke risk factors, such as high blood pressure and blood clots, nattokinase is associated with a decrease in von Willebrand factor (vWF) in people assigned as women at birth. In China, a randomized, controlled clinical trial found that nattokinase (6,000 fibrinolysis units per day) reduced the size of carotid plaque by 36%. Nattokinase is an enzyme (protein) found in natto, a traditional Japanese dish made from fermented soybeans.

Virgil Tapp
Virgil Tapp

Lifelong twitter fanatic. Devoted coffee lover. Professional bacon geek. Total bacon ninja. General musicaholic.

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