After administration of the extract, the SBP decreased significantly to 145 ± 24 mmHg in 2 h (p).
Nattokinase
consumption was associated with reduced systolic and diastolic BP. The reduction in systolic blood pressure was seen in both sexes, but was more pronounced in men who consumed nattokinase. The average reduction in diastolic blood pressure in the group receiving nattokinase, from 87 mm Hg to 84 mm Hg, was statistically significant compared to that of the placebo group, where the average diastolic blood pressure remained constant at 87 mm Hg (P.Nattokinase can also help lower blood pressure). If you have low blood pressure or are taking medicines to lower your blood pressure, be sure to talk to your doctor before taking nattokinase. The enzyme responsible for natto's health effects, nattokinase, has since been purified and studied extensively. Nattokinase keeps blood flowing optimally and promotes cardiovascular health.
According to research on this powerful enzyme, it can lower blood pressure3,4, help reduce the risk of atherosclerosis, 5,6, help lower lipids7, promote optimal blood flow thanks to its anticoagulant properties,8 and can even be neuroprotective.9 With a single compound, the list of benefits is impressive. Nattokinase may work in a similar way to the ginkgo supplement, which is also touted for its heart health benefits. And while research doesn't support the use of ginkgo to lower blood pressure or the risk of stroke, ginkgo can cause blood-thinning side effects. In another small study, nattokinase combined with standard care (SOC) could help in stroke rehabilitation.
More high-quality research is needed, with larger, well-designed clinical trials to evaluate the efficacy and safety of nattokinase. Serum levels of PF4 (CXCL) showed no difference between the nattokinase group and the placebo group (data not shown). Studies show that nattokinase dissolves blood clots, helping to maintain good blood vessel structure, improving blood flow and reducing the risk of heart disease. Its name is misleading, since nattokinase is not a kinase enzyme but a serine protease from the subtilisin family and has strong fibrinolytic activity, 21,22 thrombolytic effects,23,24 and a reduction in platelet aggregation and coagulation.
In a small clinical trial on nattokinase in people without cardiovascular diseases, no. no significant benefit was found in preventing heart disease. A new fibrinolytic enzyme (nattokinase) in Natto vegetable cheese, a typical and popular soy food in the Japanese diet. In addition, the known relationship between vWF and the ABO44 blood group could help explain the differences between the results of studies in different ethnic groups, since vWF is higher in subjects with a blood group other than type O, so that future studies on nattokinase and hypertension should monitor the blood group.
Nattokinase has also been shown to reduce acetylcholinesterase activity and inflammatory markers associated with neurodegenerative diseases. When evaluating the reduction in systolic blood pressure in the nattokinase consuming group, the decrease from 144 ± 1.5 mmHg to 140 ± 2.1 mmHg marked a statistical trend (P.However, taking nattokinase can increase the effects of aspirin, which could cause an unexpected amount of bleeding. The objective of the study was to document the efficacy of nattokinase in a North American population, along with diet, lifestyle, and associated stressors.
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